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IL-2系一种淋巴因子,分子量约15,000。近年来对其免疫调节作用做了大量的研究。IL-2主要作用于T淋巴细胞、NK细胞等。据报道,给予动物IL-2,能促进对同种抗原及肿瘤细胞的排斥。但是,由于IL-2在体内代谢极快,体内应用受到一定的限制。据报道,静脉注射IL-2后,在血中半衰期仅数分钟;腹腔或皮下注射后,半衰期亦仅2或6小时。采用IL-2与明胶混合注射的方法虽可延长半衰期,但因明胶
IL-2 is a lymphokine with a molecular weight of about 15,000. In recent years, a great deal of research has been done on its immunomodulatory effects. IL-2 mainly acts on T lymphocytes, NK cells and the like. It has been reported that administration of IL-2 to animals promotes rejection of alloantigens and tumor cells. However, due to the rapid metabolism of IL-2 in the body, in vivo applications are limited. It has been reported that the half-life in blood is only a few minutes after intravenous injection of IL-2, and half-life is only 2 or 6 hours after intraperitoneal or subcutaneous injection. Although the method of mixed injection of IL-2 and gelatin can increase the half-life, it is due to gelatin.