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The advent of sentinel lymph-node technique has led to a shift in lymph-node staging,due to the emergence of new entities namely micrometastases(p N1mi) and isolated tumor cells [p N0(i+)].The prognostic significance of this low positivity in axillary lymph nodes is currently debated,as is,therefore its management.This article provides updates evidence-based medicine data to take into account for treatment decision-making in this setting,discussing the locoregional treatment in p N0(i+) and p N1 mi patients(completion axillary dissection,axillary irradiation with or without regional nodes irradiation,or observation),according to systemic treatment,with the goal to help physicians in their daily practice.
The advent of sentinel lymph-node technique has led to a shift in lymph-node staging, due to the emergence of new entities that micrometastases (p N1mi) and isolated tumor cells [p N0 (i +)]. The prognostic significance of this low positivity in axillary lymph nodes is currently debated, as is, therefore its management. this article provides updates evidence-based medicine data to take into account for treatment decision-making in this setting, discussing the locoregional treatment in p N0 (i +) and p N1 mi patients (completion axillary dissection, axillary irradiation with or without regional nodes irradiation, or observation), according to systemic treatment, with the goal to help physicians in their daily practice.