论文部分内容阅读
报道了单分子和双分子取代苯酚类螯合剂对超氧阴离子自由基和羟自由基的清除作用及对大鼠肝线粒体辐射诱导的脂质过氧化反应的抑制作用。结果表明：取代苯酚类螯合剂具有不同程度的清除氧自由基和抗辐射脂质过氧化作用，其清除羟自由基和抑制辐射诱导的脂质过氧化作用的IC50为1ｘ10-6mol／L，清除超氧阴离子自由基的IC50为1ｘ10-9mol／L，其中7601（CB－MIDA）、9501、9502等螯合剂的能力最强，初步观察到其抗氧化作用的强弱与促排活性的构效相关联。
The scavenging effects of monomeric and bimolecularly substituted phenolic chelating agents on superoxide anion radicals and hydroxyl radicals and on the lipid peroxidation induced by mitochondrial radiation in rat liver were reported. The results showed that the substituted phenol chelating agents have different levels of scavenging oxygen free radicals and anti-radiation lipid peroxidation, the IC50 of scavenging hydroxyl radical and inhibiting radiation-induced lipid peroxidation is 1 × 10-6mol / L, The IC50 of superoxide anion radical is 1 × 10-9mol / L, of which 7601 (CB-MIDA), 9501,9502 and other chelating agents have the strongest ability. The antioxidant activity and the activity of promoting activity Associated.