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目的探讨T2DM患者心脏变时功能不全(CI)与糖脂代谢的关系。方法 138例T2DM患者分为CI组和变时功能正常组(Con),比较两组糖脂代谢指标、血尿酸(SUA)、T2DM慢性并发症、心率变异(HRV)指标,包括RR间期标准差(SDNN)和相邻RR间期之差的均方根(rMSSD)。结果CI组2 hPG、HbA_1c、TC、TG和SUA高于Con组(t=2.067、3.640、3.699、2.120、3.740,P<0.05);CI组DPN患病率高于Con组(x~2=8.067,P<0.05);CI组SDNN、rMSSD较Con组降低(t=-8.157、-2.149,P<0.05)。多元Logistic回归分析结果显示,HbA_1c、TC、SUA和SDNN为CI的独立影响因素(OR=1.242、1.734、1.006、0.914,P<0.05)。结论长期、慢性的高血糖、高血脂可能是T2DM患者发生CI的重要因素,同时合并CI患者HRV降低。
Objective To investigate the relationship between cardiac dysfunction (CI) and glucose and lipid metabolism in T2DM patients. Methods One hundred and thirty-eight patients with T2DM were divided into CI group and normal control group (Con). The levels of glucose and lipid metabolism, serum uric acid (SUA), T2DM chronic complications and heart rate variability (HRV) Difference root mean square (rMSSD) between the difference (SDNN) and the adjacent RR interval. Results The prevalence of DPN in CI group was higher than that in Con group (t = 2.067,3.640,3.699,2.120,3.740, P <0.05) 8.067, P <0.05). SDNN and rMSSD in CI group were lower than those in Con group (t = -8.157, -2.149, P <0.05). Multivariate logistic regression analysis showed that HbA 1c, TC, SUA and SDNN were the independent influential factors of CI (OR = 1.242,1.734,1.006,0.914, P <0.05). Conclusions Long-term and chronic hyperglycemia and hyperlipidemia may be important factors in the development of CI in patients with T2DM, and the HRV in patients with CI may be decreased.