蕨藻素(caulerpin),小鼠口服的最大耐受量为134.74mg/kg,灌胃给药或静脉注射caulerpin对腹腔注射醋酸所致小鼠的扭体反应无影响;皮下注射caulerpin对扭体反应有一定抑制作用,但镇痛百分率<50％;腹腔注射caulerpin对醋酸所致小鼠的扭体反应有显著的抑制作用,其ID_(50)=1.088±0.125mg/kg,当给药剂量≥10mg/kg时,镇痛百分率为100％。 The maximum tolerated dose of oral fertilization in mice was 134.74 mg/kg. No effect was found by intragastric administration of caulerpin or by intraperitoneal injection of acetic acid on the writhing of mice; subcutaneous injection of caulerpin on writhing The reaction had a certain inhibitory effect, but the percentage of analgesia was less than 50%; intraperitoneal injection of caulerpin significantly inhibited the writhing response of mice induced by acetic acid. The ID_(50) was 1.088±0.125 mg/kg when the dose was administered. When ≥10mg/kg, the percentage of analgesia is 100%.