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用微生物法对健康狗口服ＩＭＢ－８６００１５０、２５、１２．５ｍｇ／ｋｇ的血药浓度及大鼠口服５０ｍｇ／ｋｇ的血药浓度进行了测定，并利用计算机程序对结果进行处理。两种动物均符合二室模型。不同种动物间药动学参数有差异，本品在大鼠体内过程较狗快。狗口服本品，血药浓度与剂量呈一定比例关系。对禁食与非禁食大鼠口服５０ｍｇ／ｋｇ，２４ｈ尿药回收率较高。食物对本品的吸收未见显著影响，但可延缓吸收。ＩＭＢ－８６００１具有较优越的体内性质。
The blood concentration of IMB-8600150, 25, 12.5 mg / kg and the oral plasma concentration of 50 mg / kg in rats were determined by microbiological method. The results were processed by computer program. Both animals conform to the two-compartment model. Different species of pharmacokinetic parameters are different, the goods in the body faster than dogs in the process. Dog oral administration of this product, plasma concentration and dose was a certain proportion of relationship. Fasting and non-fasting rats oral 50mg / kg, 24h urinary drug recovery rate higher. No significant effect of food on the absorption of this product, but can delay absorption. IMB-86001 has superior in vivo properties.