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目的观察同侧短暂性缺血发作(TIA)对后继大面积脑梗死的影响。方法将51例首次发病的大面积脑梗死患者,按照是否预先发生同侧的TIA及发生间隔进行分组,采用欧洲卒中评分方法在治疗前及治疗3周时评价各组患者神经功能缺损程度。结果发病前4周有TIA发生的脑梗死患者较无TIA发作的脑梗死患者入院时及治疗3周后欧洲脑卒中评分有差异(P<0.05),TIA发生时间小于1周者入院时及3周后评分好于病前2～4周发生TIA者,但仅入院时有统计学意义(P<0.05)。结论脑梗死前发生的同侧TIA可能产生缺血耐受现象,对后继发生的脑梗死起保护作用。
Objective To observe the effect of ipsilateral transient ischemic attack (TIA) on subsequent large area cerebral infarction. Methods Fifty-one patients with first-onset large-area cerebral infarction were divided into groups according to whether there was pre-existing ipsilateral TIA and interval. The European stroke score was used to evaluate the degree of neurological deficits before and 3 weeks after treatment. Results Compared with those without cerebral infarction (TIA), the incidence of stroke in the patients with TIA 4 weeks before admission and after 3 weeks of treatment were significantly different (P <0.05), those with TIA less than 1 week admission and 3 TIA scores were better than weeks 2 to 4 before admission, but only statistically significant at admission (P <0.05). Conclusion The ipsilateral TIA occurred before cerebral infarction may cause ischemic tolerance, which may protect the subsequent cerebral infarction.