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近年来随着分子生物研究和认识的不断深入,P~53的归类在经历了肿瘤抗愿,癌旦白和肿瘤抑制因子三个阶段之后。现己证实野生型P~(53)(P~(53)wt)基因是一类重要的抗癌基因,它的缺失,突变和灭活,在人类许多肿瘤的激发和进展过程中已是非常普遍的现象。 1 P~(53)基因的分类特点 P~(53)是被修饰或者与细胞周期有关调节旦白结合的一种串衰期很短的核磷旦白。核旦白能抑制肿瘤细胞系的生长和动物肿瘤
In recent years, with the deepening of research and understanding of molecular biology, the classification of P~53 has gone through three phases: cancer resistance, cancer whitening, and tumor suppressor factors. It has been confirmed that the wild-type P53 (P53 wt) gene is an important type of anti-oncogene. Its deletion, mutation and inactivation have been very high during the initiation and progression of many human tumors. common phenomenon. 1 The classification characteristics of P53 gene P53 is a kind of nuclear phosphorescence with very short string-life, which is modified or regulated by cell cycle. Nuclear can inhibit the growth of tumor cell lines and animal tumors