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为研究食管癌、肺癌病人围手术期应用化疗药物对机体免疫功能的影响，通过应用ＯＫＴ系列单克隆抗体，对３０例食管癌、肺癌患者进行围手术期化疗前后外周Ｔ淋巴细胞亚群的动态检测，结果显示，术前化疗组患者ＯＫＴ￣＋＿２、ＯＫＴ￣＋＿４ＯＫＴ￣＋＿８均明显下降，但ＯＫＴ￣＋＿４／ＯＫＴ￣＋＿８比值无变化；术后应用小剂量５－氟脲嘧啶，可选择性抑制ＯＫＴ细胞亚群，促进机体免疫功能的恢复。结果说明：术前化疗可使免疫活性细胞明显损伤，不利于术后免疫功能的恢复，而术后化疗有促进免疫的效应。
To study the effect of perioperative chemotherapy drugs on immune function in patients with esophageal and lung cancer, and to apply the OKT series of monoclonal antibodies to the dynamics of peripheral T lymphocyte subsets before and after perioperative chemotherapy in 30 patients with esophageal or lung cancer. The results showed that OKT ̄+2 and OKT ̄+4OKT ̄+_8 decreased significantly in the preoperative chemotherapy group, but there was no change in the OKT ̄+_4/OKT ̄+ _8 ratio; postoperative low-dose 5-fluorouracil could be selectively suppressed OKT cell subpopulations promote recovery of immune function. The results showed that preoperative chemotherapy can significantly damage the immunocompetent cells, which is not conducive to the recovery of immune function after surgery, and postoperative chemotherapy has the effect of promoting immunity.