什么是新生儿高胆红素血症在新生儿期(生后7～10天左右),由于各种原因使胆红素代谢发生障碍,致使血浆内胆红素浓度增高,超出了正常生理范围即为高胆红素血症(成熟新生儿血胆红素浓度大于12毫克%.未成熟新生儿血胆红素浓度大于15毫克%).高胆红素血症的主要危险是引起核黄疸。什么是核黄疸及其危害当血清胆红素浓度增高到20mg%,间接(未结合)胆红素为脂溶性和亲脂性时,血清胆红素与富有脑磷脂的脑组织有亲和力(而水溶性的直接胆红素增高与核黄疸发生无关).间接胆红素进入脑细胞,使脑细胞内线粒体氧化磷酸化的偶联作用脱节,脑细胞的能量产生受到抑制,使脑组织受损,导致神经细胞中毒变性,故称核黄疸,又叫胆红素脑病.发生核黄疸时,新生儿可出现黄疸加深,不安或嗜睡,肌张力减低,吸吮反射减弱,发热,痉挛,颈项强直,角弓反张,眼球斜视,震颤,抽 What is neonatal hyperbilirubinemia in the neonatal period (after birth, about 7 to 10 days), due to various reasons, obstruction of bilirubin metabolism, resulting in plasma bilirubin concentration increased beyond the normal physiological range Is hyperbilirubinemia (mature neonates with a serum bilirubin concentration greater than 12 mg% and an immature neonator with a serum bilirubin concentration greater than 15 mg%.) The primary danger of hyperbilirubinemia is kernicterus . What is kernicterus and its harm Serum bilirubin has affinity for brain-rich brain phosphatide when the serum bilirubin concentration is increased to 20 mg% and indirect (unbound) bilirubin is lipophilic and lipophilic Of the direct bilirubin has nothing to do with the occurrence of nuclear jaundice.) Indirect bilirubin into the brain cells, brain cells mitochondrial oxidative phosphorylation coupling out of line, brain cell energy production is inhibited, so that brain tissue damage, resulting in Nerve cell degeneration, it said nuclear jaundice, also known as bilirubin encephalopathy .If nuclear jaundice, neonatal jaundice may deepen, restlessness or drowsiness, decreased muscle tone, sucking reflex, fever, spasms, neck stiffness, angle bow Anti-Zhang, strabismus, tremor, pumping