论文部分内容阅读
目的:观察补肾活血中药对肾虚型膝骨关节炎(kneeosteoarthritis,KOA)的治疗作用.方法雌性SD大鼠54只,造模成功后,随机分为:中药组,双醋瑞因组,模型组,每组18只.分别在用药后2,4,8周各组随机处死动物6只,行动物软骨的组织病理学观察、血清雌二醇(estradiol,E2)水平检测.结果模型组关节表面缺损,软骨厚度有明显变薄,软骨同源细胞数目减少.双醋瑞因组与模型组相似.中药组在软骨厚度及软骨同源细胞数方面都优于模型组与双醋瑞因组(P<0.05).E2水平补肾中药组显著高于模型组和双醋瑞因组.结论补肾活血中药有一定修复和延缓膝骨关节炎软骨退变的作用. “,”Objective Observation the therapeutical effect of Herbs Invigorating Kidney on knee osteoarthritis(KOA). Methods After the models were established, 54 female SD rats were randomly divided into 3 groups:the herb group, Shuangcuruiyin group, the model control group. At three time points (2 weeks, 4 weeks, 8 weeks) after respective treatments, six rats in each group were randomly selected and sacriifced. Tissue samples (cartilage, synovia, and blood) were collected and analyzed using histopathological and E2. Results In the model group, the surface of arthrosis cartilage was not smooth, the thickness of cartilage was dramatically reduced and there were a large amount of dead cartilage cells. The number of isogeneous group of cartilage decreased. Shuangcuruiyin group had the similar results as the model group. Results from the herb group were better than those from the model group in terms of the thickness of cartilage and the number of isogeneous group of cartilage. The E2 level in herbs invigorating kidney (HIK) group of was signiifcantly higher than that in the model group and Shuangcuruiyin group .Conclusion HIK have some curative effectiveness on KOA.