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目的探讨幽门螺旋杆菌(Hp)感染患者血清中抗体与各种疾病的关系。方法利用蛋白芯片技术检测7组研究对象共2940例,其中慢性胃炎1693例、消化性溃疡383例、胃肠道肿瘤82例、其他肿瘤249例、肝脏疾病195例、HIV或AIDS 109例、以及对照组肺结核患者(TB)229例。血清Hp的3种抗体:CagA抗体、VacA抗体和Ure抗体。结果慢性胃炎组的3种抗体的阳性率分别为1.4%、4.4%和24.5%;消化性溃疡组为1.3%、4.4%和33.9%;消化道肿瘤组为7.3%、15.8%和28.0%;其他肿瘤组为4.4%、10.8%和31.7%;肝脏疾病为1.5%、6.1%和33.3%;HIV/AIDS组为0.9%、8.2%和34.8%;对照组(TB)分别为1.3%、5.2%和24.0%。胃肠道肿瘤组、其它肿瘤组抗体阳性率与对照组比较差异具有统计学意义(P<0.05)。其余各组与对照组比较抗体阳性率差异无统计学意义(P>0.05)。结论提示不同抗体的存在可能与肿瘤有一定的关系,但3种抗体与消化道、呼吸道、肝脏等疾病无甄别关系。所有疾病抗体阳性率均低于50%,用于诊断幽门螺旋杆菌感染价值不大。
Objective To investigate the relationship between serum antibodies and various diseases in patients with Helicobacter pylori (Hp) infection. Methods A total of 2940 subjects were examined by protein chip technique. Among them, 1693 were chronic gastritis, 383 were peptic ulcer, 82 were gastrointestinal cancer, 249 were other tumors, 195 were liver disease, 109 were HIV or AIDS, and Control group of tuberculosis patients (TB) in 229 cases. Three kinds of serum Hp antibodies: CagA antibody, VacA antibody and Ure antibody. Results The positive rates of the three antibodies in the chronic gastritis group were 1.4%, 4.4% and 24.5% respectively; those in the peptic ulcer group were 1.3%, 4.4% and 33.9%; those in the gastrointestinal cancer group were 7.3%, 15.8% and 28.0%, respectively. The incidence of liver disease was 1.5%, 6.1% and 33.3% in other tumor groups, and was 0.9%, 8.2% and 34.8% in HIV / AIDS group and 1.3% and 5.2% in control group % And 24.0%. The positive rate of antibody in gastrointestinal tumor group and other tumor groups was statistically significant compared with the control group (P <0.05). There was no significant difference in antibody positive rate between the other groups and the control group (P> 0.05). Conclusions suggest that the presence of different antibodies may have a certain relationship with the tumor, but the three antibodies and the digestive tract, respiratory tract, liver and other diseases no screening relationship. The positive rate of all disease antibodies were less than 50%, for the diagnosis of Helicobacter pylori infection little value.