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病毒性呼吸器官的感染是诱发支气管喘息或引起伴有喘鸣的喘息原因,然而有关两者关系的基础研究尚无更多资料。井田等报告,在试管中给人的末梢白细胞中加进病毒,经一定时间培养即产生干扰素(interferon),这种干扰素作用于嗜硷细胞,使化学介质游离增强,并使受干扰素诱导的细胞产生组胺增加因子,细胞内环磷酸腺苷(cAMP)水平下降。Friek等也阐明了乳儿的变态反应性过敏的发病与病毒感染的关系,他们就上呼吸道感染的前后加以比较,发现感染后的IgE和放射免疫吸附试验与组织胺释放较感染前均有增加。因而推想可能是病毒感染使T细胞和B细胞发生改变,引起变态反应性过敏状态。
Infection with viral respiratory organs is a cause of bronchial asthma or wheezing associated wheeze. However, there is no further information on the basic research on the relationship between the two. Ida et al. Report adding virus to peripheral leukocytes in test tubes and producing interferon after a certain period of incubation. This interferon acts on basophils to make the chemical mediator free and enhance the release of interferon Induced cells produce histamine increase factor, cellular cAMP levels decreased. Friek et al. Also clarified the relationship between the incidence of allergic reactions in infants and viral infections and compared them before and after upper respiratory tract infection, and found that post-infection IgE and radioimmunoassay increased with histamine release before infection. Thus it is assumed that the virus infection may make T cells and B cells change, causing allergic allergic states.