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目的探讨肿瘤标志物CA125、CA153、癌胚抗原(CEA)及甲胎蛋白(AFP)的联合检测对卵巢癌的诊断价值。方法 CA125、CA153检测采用磁微粒化学发光法;CEA、AFP采用ELISA法,共检测104例妇科附件肿物患者,并进行比较分析。结果卵巢肿物恶性组血清CA125、CA153、CEA及AFP结果显著高于良性组和对照组,差异有统计学意义(P<0.05)。联合检测的敏感性、特异性、准确度分别为93.2%(41/44)、88.3%(53/60)、90.4(94/104),都高于单项检测结果。结论血清CA125、CA153、CEA及AFP的联合检测有助于提高卵巢恶性肿瘤的诊断率。
Objective To investigate the diagnostic value of tumor markers CA125, CA153, carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in ovarian cancer. Methods CA125 and CA153 were detected by magnetic particle chemiluminescence method. CEA and AFP were detected by ELISA in 104 patients with gynecological attachments. The comparative analysis was made. Results The results of serum CA125, CA153, CEA and AFP in ovarian malignant group were significantly higher than those in benign group and control group (P <0.05). The sensitivity, specificity and accuracy of the combined detection were 93.2% (41/44), 88.3% (53/60) and 90.4 (94/104), respectively, which were higher than the individual test results. Conclusion The combined detection of serum CA125, CA153, CEA and AFP may help to improve the diagnosis of ovarian cancer.