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目的：初步评价最新的诊断技术９９Ｔｃｍ－ＥＣＤ脑 ＳＰＥＣＴ双嘧达莫负荷显像在颈内动脉系统短暂脑缺血发作（ＴＩＡ）患者中的应用价值，并与脑 ＳＰＥＣＴ静息显像和头颅 ＭＲＩ相比较。方法：对 １４例颈内动脉系统 ＴＩＡ患者在发作间期进行９９Ｔｃｍ－ＥＣＤ脑ＳＰＥＣＴ静息和双嘧达莫负荷显像及头颅ＭＲＩ检查。结果：脑ＳＰＥＣＴ双嘧达莫负荷显像与静息显像相比较，共有１０例患者在负荷状态下，局部放射性稀疏的程度较静息显像明显加重。在６例脑ＳＰＥＣＴ静息显像无异常的患者中，４例在双嘧达莫负荷情况下诱导出了与ＴＩＡ发作期临床表现相应的脑功能部位的脑血流灌注不足。与头颅ＭＲＩ比较，９例ＭＲＩ阴性的患者在脑ＳＰＥＣＴ双嘧达莫负荷显像中显示出了局部放射性稀疏。结论：本研究结果说明双嘧达莫负荷脑ＳＰＥＣＴ显像对ＴＩＡ患者脑血流储备能力的评价是有价值的。如果能应用定量或半定量的方法计算ｒＣＢＦ的变化程度，则更有临床意义。
OBJECTIVE: To evaluate the value of 99Tcm-ECD brain SPECT dipyridamole imaging in patients with transient ischemic attack of internal carotid artery (TIA) Compared. Methods: Fourteen patients with internal carotid artery TIA underwent 99Tcm-ECD brain SPECT and dipyridamole imaging and cranial MRI in the interictal period. Results: Compared with resting imaging, the dipyridamole-bearing SPECT imaging showed that in 10 patients, the degree of local radioactive sparseness was significantly higher than that of resting imaging under load. Of the 6 patients with no abnormalities in resting SPECT images, 4 induced cerebral hypoperfusion at the brain functional site corresponding to the clinical presentation of the TIA during dipyridamole loading. Compared with cranial MRI, nine patients with MRI negative showed localized radioactivity sparse in brain SPECT dipyridamole imaging. CONCLUSIONS: The results of this study demonstrate the value of dipyridamole-loaded SPECT imaging in assessing cerebral blood flow reserve in TIA patients. If we can use quantitative or semi-quantitative method to calculate the degree of change in rCBF, more clinical significance.