准确而迅速地获得人体生理参数的变量,是生物医学工程的一项重要研究内容。本文将介绍离子敏感场效应晶体管型微电极。这是特定离子电极和酶电极技术与半导体集成电路技术相结合而研制成功的新型微型电极,它利用裸露栅和聚合物离子选择性栅膜来制造离子敏感场效应晶体管。本文将描述能同时或独立地测定体内H和Na离子活度的微电极(微型集成多离子传感器)的制造。离子敏感场效应晶体管微电极的作用原理与相应的离子敏感聚合物膜电极相同。该聚合物膜直接与场效应晶体管的栅隔离体相接触。在离子敏感的聚合物膜和溶液的界面上产生Nernst电势并传给栅。离子敏感场效 Accurate and rapid access to human physiological parameters of variables, is an important study of biomedical engineering. This article describes ion-sensitive field-effect transistor-based microelectrodes. This is a new type of microelectrode developed with the combination of specific ion and enzyme electrode technology and semiconductor integrated circuit technology. It uses an exposed gate and a polymer ion-selective gate film to make an ion-sensitive field-effect transistor. Herein we will describe the fabrication of microelectrodes (micro-integrated multi-ion sensors) that can measure the H and Na ion activity in vivo simultaneously or independently. Ion-sensitive field effect transistor microelectrodes and the corresponding role of the principle of the corresponding ion-sensitive polymer membrane electrode. The polymer film is in direct contact with the gate insulator of the field effect transistor. A Nernst potential is generated at the interface of the ion-sensitive polymer film and the solution and transferred to the grid. Ion-sensitive field effect