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卒中后抑郁（ PSD）是脑卒中的常见并发症之一，可产生悲观、兴趣下降、睡眠障碍、注意力不集中、易激惹等症状。 PSD可明显影响卒中的预后，并且其产生的认知障碍容易与卒中本身的躯体症状相混淆。 PSD患者给家庭及社会带来了沉重的负担，因而提高临床医师对PSD的认识水平相当重要。脑神经营养因子（ BDNF）广泛地存在中枢及外周神经系统中，越来越多的学者认识到了它的神经修复能力，更多的研究开始关注BDNF在PSD发生过程中的作用，同样更加重视其在 PSD 治疗过程中的效果。现对BDNF的基础作用及其与PSD的最新研究成果进行综述。“,”Post-stroke depression(PSD) is a common complication of stroke,with the symptoms of pessi-mistic,interest decline,sleep disorders,inattention,irritability and so on.Its assessment and treatment is often overlooked.PSD can significantly affect the prognosis of stroke,cognitive disorders,which can be easily con-fused with physical symptoms.Thus further strengthening of the clinician awareness of PSD is very important . Braind-erived neurotrophic factor ( BDNF) is widespread in central and peripheral nervous systems ,and more and more scholars recognize its nerve repair capability,and more researches began to focus on the process of BDNF in PSD,and more attention is being paid to its therapeutic effect on PSD .Here is to make a review of the fundamental role of BDNF and its latest research results in PSD .