论文部分内容阅读
目的探讨高血压时血浆胆固醇（Ｃｈｏ）、甘油三酯（ＴＧ）和高密度脂蛋白（ＨＤＬ－Ｃ）水平与细胞膜离子运输酶活性之间的关系。方法３２名正常人（ＮＴ），５５例原发性高血压（ＨＴ）患者，检测血浆Ｃｈｏ、ＴＧ、ＨＤＬ－Ｃ水平，红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶和Ｃａ２＋－ＡＴＰ酶活性，膜Ｃ／Ｐ克分子比率及膜内面Ｃａ２＋结合力。结果（１）ＨＴ组平均动脉血压（ＭＡＰ）与ＮＴ组相比有显著性差别；（２）ＨＴ组血浆ＨＤＬ－Ｃ水平、红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶和Ｃａ２＋－ＡＴＰ酶活性，以及膜内面Ｃａ２＋结合力均较ＮＴ组明显减低；（３）ＨＴ组血浆Ｃｈｏ，ＴＧ水平、红细胞膜Ｃｈｏ含量和Ｃ／Ｐ克分子比率，与ＮＴ组比较皆明显增高。结论红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶和Ｃａ２＋－ＡＴＰ酶活性减低，以及膜内面Ｃａ２＋结合力减低，是高血压时细胞膜离子运输失常的主要标志，血浆ＴＧ水平升高和膜磷脂水平减低可能是高血压时细胞膜理化特性及离子运输失常的主要决定因素。
Objective To investigate the relationship between plasma cholesterol (Cho), triglyceride (TG) and high density lipoprotein (HDL-C) levels and plasma membrane ion transport enzyme activity in patients with hypertension. Methods The plasma levels of Cho, TG, HDL-C, erythrocyte membrane Na + -K + -ATPase and Ca2 + -ATPase activity were measured in 32 normal subjects (NT) and 55 patients with primary hypertension (HT) P mole ratio and membrane Ca2 + binding capacity. Results (1) The mean arterial blood pressure (MAP) in HT group was significantly different from that in NT group. (2) The levels of plasma HDL-C and Na + -K + -ATPase and Ca2 + -ATPase activity in HT group, (3) The levels of Cho, TG, Cho and erythrocyte membrane C / P ratio in HT group were significantly higher than those in NT group. Conclusions The decrease of Na + -K + -ATPase and Ca2 + -ATPase activity in erythrocyte membrane and the decrease of Ca2 + binding capacity in erythrocyte membrane are the main markers of plasma membrane ion transport disorder in hypertension. The plasma TG level and the decrease of membrane phospholipid level may be high Blood pressure physical and chemical properties of cell membranes and ion transport disorders of the main determinants.