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[目的]观察小柴胡片联合干扰素(IFN)治疗慢性乙型肝炎(CHB)肝纤维化的临床疗效。[方法]选择CHB患者137例,随机分为2组,对照组(64例)用IFN300万U隔日1次肌内注射,治疗组(73例)加用小柴胡片,疗程均为6个月,观察2组治疗前、后肝纤维化及影像学指标的变化。[结果]2组疗程结束后肝功能和肝纤维化指标均有明显改善,治疗组优于对照组,且能改善影像学指标(P<0.05,<0.01)。[结论]小柴胡片与IFN联合应用对CHB具有较好的临床疗效,在改善肝纤维化方面两药合用具有协同作用。
[Objective] To observe the clinical effect of Xiaobaihuo Tablet combined with interferon (IFN) in treating chronic hepatitis B (CHB) liver fibrosis. [Methods] A total of 137 CHB patients were randomly divided into 2 groups. The control group (64 cases) was given intramuscular injection of IFN300k once every other day, and the treatment group (73 cases) plus Xiaochaihuo tablets for 6 months The changes of hepatic fibrosis and imaging indexes before and after treatment were observed in two groups. [Results] The indexes of liver function and liver fibrosis in both groups after treatment were significantly improved. The treatment group was better than the control group, and the imaging indexes were improved (P <0.05, <0.01). [Conclusion] The combination of Xiaobaihu tablets and IFN has a good clinical curative effect on CHB, and there is a synergistic effect between the two drugs in improving hepatic fibrosis.