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本文用放免法测定了３３例十二指肠球部溃疡及３５例慢性胃炎患者血浆胃动素水平，同时检测胃粘膜ＨＰ感染情况及胃液ｐＨ值，并对其中１９例十二指肠球部溃疡患者进行抗ＨＰ二联治疗（得乐冲剂＋甲硝唑片）共６周，观察ＨＰ转阴后胃动素变化，结果表明十二指肠球部溃疡患者血浆胃动素显著高于慢性胃炎患者，分别为４４７．２３±９８．４ｎｇ／Ｌ及３５３．５±１００．２ｎｇ／Ｌ（Ｐ＜０．０１），１７例溃疡愈合者血浆胃动素显著下降，与慢性胃炎愈合者无显著性差异（Ｐ＞０．０５），而２例溃疡未愈者血浆胃动素仍持续升高，相关分析显示十二指肠球部溃疡患者血浆胃动素升高与ＨＰ感染及胃液ｐＨ值无关。本文认为十二指肠球部溃疡患者血浆胃动素升高可能是一种继发性改变，其临床意义尚有待进一步阐明。
In this paper, 33 patients with duodenal ulcer and 35 patients with chronic gastritis were assayed for plasma motilin level by radioimmunoassay, meanwhile HP infection of gastric mucosa and pH of gastric juice were detected. Among them, 19 cases of duodenal bulb Ulcer patients were treated with anti-HP combination therapy (Dele granules + metronidazole tablets) for 6 weeks to observe the changes of motilin after HP negative conversion. The results showed that the plasma motilin in patients with duodenal ulcer was significantly higher than that in chronic Gastritis patients were 447.23 ± 98.4ng / L and 353.5 ± 100.2ng / L, respectively (P <0.01). The plasma motilin of 17 patients with ulcer healed significantly decreased, while those with chronic gastritis had no symptoms (P> 0.05). However, the level of plasma motilin in 2 patients with ulcer still continued to increase. The correlation analysis showed that plasma motilin increased with HP infection and gastric juice pH Value has nothing to do. This paper suggests that elevated plasma motilin in patients with duodenal ulcer may be a secondary change, its clinical significance remains to be further elucidated.