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目的 :了解喉癌组织中环氧化酶 2 (Cox 2 )及p5 3的表达 ,探讨Cox 2在喉癌发生发展中的作用及与p5 3之间的关系。 方法 :采用免疫组织化学方法检测 6 3例喉癌组织中Cox 2与 p5 3的表达情况。 结果 :6 3例喉癌标本中Cox 2阳性表达率为 5 8.7% (37/6 3) ,患者的不同临床分期的表达差异有统计学意义 (P <0 .0 5 )。p5 3的阳性表达率为 6 3.5 % (4 0 /6 3) ,不同组织病理学分级的 p5 3阳性表达的差异有统计学意义 (P <0 .0 5 ) ;Cox 2与p5 3之间存在等级相关性。结论 :Cox 2能促进喉癌的生长、增殖与浸润 ,应用Cox 2抑制剂可望对喉癌的发展起到抑制作用
Objective: To investigate the expressions of Cox 2 and p5 3 in laryngeal carcinoma and to explore the role of Cox 2 in the development and progression of laryngeal carcinoma and its relationship with p5 3. Methods: The expressions of Cox 2 and p53 in 63 cases of laryngeal carcinoma were detected by immunohistochemistry. Results: The positive expression rate of Cox 2 in 67 specimens of laryngeal cancer was 57.7% (37/6 3). There were significant differences in the expression of Cox 2 in different clinical stages (P <0.05). The positive rate of p5 3 expression was 65.5% (40/63). There was significant difference in the expression of p53 between different pathological grades (P <0.05), between Cox 2 and p5 3 There is a rank correlation. CONCLUSION: Cox 2 can promote the growth, proliferation and infiltration of laryngeal carcinoma. The application of Cox 2 inhibitor is expected to have an inhibitory effect on the development of laryngeal carcinoma