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目的探讨多发性硬化(multiplesclerosis,MS)患者中合并癫的情况。方法回顾1981—2004年北京协和医院收治的临床确诊和实验室支持确诊的MS患者119例,分析其中合并癫患者的临床特点。结果MS患者发生癫的患病率为5.0%±0.1%,明显高于普通人群患病率的0.5%～1.0%。但是起病年龄、额叶皮质下以及侧脑室旁病灶、年复发率及扩展功能障碍状态量表(EDSS)评分与多发性硬化患者是否出现癫无统计学明显相关。颞叶皮质下病灶与多发性硬化患者出现癫存在统计学相关(P=0.035)。结论MS患者较普通人群易患癫,其中存在颞叶皮质下病灶的MS患者更易出现癫。
Objective To explore the situation of combined epilepsy in patients with multiple sclerosis (MS). Methods A retrospective review of 119 patients with clinically confirmed and laboratory-confirmed MS in our hospital from 1981 to 2004 in Peking Union Medical College Hospital was conducted. The clinical features of patients with epilepsy were analyzed. Results The prevalence of epilepsy in MS patients was 5.0% ± 0.1%, which was significantly higher than that of the general population (0.5% -1.0%). However, age at onset, frontal cortex and paraventricular foci, annual recurrence rate and extended dysfunction status scale (EDSS) score were significantly correlated with whether epilepsy was found in patients with multiple sclerosis. There was a statistically significant correlation between temporal lobe cortical lesions and epilepsy in patients with multiple sclerosis (P = 0.035). Conclusion MS patients are more susceptible to epilepsy than the general population, and MS patients with temporal lobe subcortical lesions are more likely to develop epilepsy.