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目的:研究盐酸氨基葡萄糖片联合玻璃酸钠治疗颞下颌关节骨关节炎(TMJOA)的临床疗效,为临床治疗提供依据。方法:选取2012年11月到2015年11月我院收治的TMJOA患者60例,按照随机数字表法将患者分为研究组和对照组,每组30例,两组均给予玻璃酸钠关节腔注射,研究组在此基础上给予盐酸氨基葡萄糖片治疗,应用视觉模拟评分法(VAS)评价关节疼痛情况,比较两组临床疗效和不良反应,比较治疗前后两组最大张口度、张口VAS评分和张口偏斜。结果:研究组总有效率为83.33%(25/30),显著高于对照组的56.67%(17/30),比较差异具有统计学意义(P<0.05);治疗后两组张口VAS评分和张口偏斜显著降低,最大张口度显著增高,且研究组显著优于对照组,比较差异具有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:盐酸氨基葡萄糖片联合玻璃酸钠治疗TMJOA具有较好的临床疗效,能有效改善患者关节功能。
Objective: To study the clinical efficacy of glucosamine hydrochloride tablets combined with sodium hyaluronate in the treatment of temporomandibular joint osteoarthritis (TMJOA) and provide the basis for clinical treatment. Methods: Totally 60 patients with TMJOA admitted to our hospital from November 2012 to November 2015 were divided into study group and control group according to the random number table method, 30 cases in each group. Both groups were given sodium hyaluronate joint cavity The study group was given glucosamine hydrochloride tablets on the basis of this study. Visual analogue scale (VAS) was used to evaluate the joint pain. The clinical curative effect and adverse reaction were compared between the two groups. The maximal mouth opening, VAS score and Skew skewed Results: The total effective rate in the study group was 83.33% (25/30), significantly higher than that in the control group (56.67%, 17/30), with significant difference (P <0.05) (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05), but there was no significant difference between the two groups (P> 0.05) . Conclusion: The combination of glucosamine hydrochloride and sodium hyaluronate has good clinical efficacy and can effectively improve the joint function of patients.