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目的探讨冠心病患者血清尿酸、胆红素水平变化及其临床意义。方法应用冠状动脉造影法诊断冠心病,根据造影结果分为冠心病组和非冠心病组,并根据病变累及范围分为单支单处病变组与多支多处病变组,应用日立7021全自动生化分析仪测定血清尿酸及胆红素浓度。结果冠心病组血清尿酸及胆红素均值显著高于非冠心病组(P<0.05);冠心病单支单处病变组与多支多处病变组的血清尿酸及胆红素水平无显著性差异(P>0.05)。结论血清尿酸水平的升高和/或胆红素水平的降低在冠心病发生、发展中具有一定的作用,但其水平的高低对冠状动脉病变范围影响不大。
Objective To investigate the changes of serum uric acid and bilirubin in patients with coronary heart disease and its clinical significance. Methods Coronary artery disease was diagnosed by coronary angiography. According to the results of angiography, the patients were divided into coronary heart disease group and non-coronary heart disease group. According to the extent of lesions, the patients were divided into single branch single disease group and multi-branch multiple lesion group. Biochemical analyzer determination of serum uric acid and bilirubin concentrations. Results The serum uric acid and bilirubin in CHD patients were significantly higher than those in non-CHD patients (P <0.05). Serum uric acid and bilirubin levels were not significantly different between patients with single coronary disease and those with multiple lesions Difference (P> 0.05). Conclusion The increase of serum uric acid level and / or the decrease of bilirubin level play a certain role in the occurrence and development of coronary heart disease. However, the level of serum uric acid has little effect on the extent of coronary artery disease.