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近年来发现，ＩＦＮ－Ｙ可与ＩＬ－２／ＩＮＦ－ａ／ＴＮＦ－Ｂ／ＬＰ协同诱导巨噬细胞（Ｍ）产生大量的一氧化氦（ＮＯ）。ＮＯ作为活化Ｍ的一种细胞毒效应分子，在抑制和杀伤寄生虫的杭感染免疫中起重要作用。ＮＯ通过作用于宿主细胞的线粒体呼吸酶、ＤＮＡ合成酶及顺乌头酸酶，与这些酶的活性部位一Ｆｅ－Ｓ基结合，形成铁－亚硝酰基复合物，抑制酶的活性，从而阻断靶细胞的能量合成及ＤＮＡ复制，引起宿主细胞的死亡。
It has been found in recent years that IFN-γ synergizes with IL-2 / INF-a / TNF-B / LP to induce macrophage (M) to produce large amounts of nitric oxide (NO). NO, a cytotoxic effector molecule that activates M, plays an important role in the suppression and killing of parasitic Hang-infected immunity. NO acts on the host cell mitochondrial respiratory enzyme, DNA synthase and aconitase, with the active site of these enzymes a Fe-S group to form iron - nitrosyl complexes, inhibit the activity of the enzyme, which resistance Disruption of target cell energy synthesis and DNA replication, leading to the death of host cells.