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目的:分析我院新生儿早发型与晚发型败血症的病原菌分布及抗生素耐药情况,检测感染凝固酶阴性葡萄球菌(Co NS)和耐甲氧西林凝固酶阴性葡萄球菌(MRCN)的耐药情况,为抗Co NS和抗MRCN感染治疗提供参考。方法:选择2010年至2015年我院儿科收治、血培养阳性并符合新生儿败血症诊断标准的患儿138例,对致病菌及药物敏感试验进行回顾性分析。结果:血培养检出病原菌24种共140株(其中136例为单一菌株感染,2例为双重菌株感染),以Co NS的检出率最高,为80.0%(112/140)。140株病原菌中检出MRCN 81株,耐甲氧西林金黄色葡萄球菌(MRSA)1株。81株MRCN的药敏试验显示对青霉素、氨苄西林、阿莫西林/克拉维酸、头孢唑林、红霉素、亚胺培南、克林霉素的耐药率分别为93.8%(76/81)、86.4%(70/81)、81.5%(66/81)、75.3%(61/81)、72.8%(59/81)、64.2%(52/81)和45.7%(37/81),未发现对万古霉素和利奈唑胺耐药的菌株。结论:我院新生儿败血症病原菌以MRCN检出率高,临床应合理应用抗生素,以提高临床治疗效果。
OBJECTIVE: To analyze the distribution of pathogens and their antibiotic resistance in neonates with early-onset and late-onset sepsis in our hospital, and to detect the drug resistance of coagulase-negative staphylococci (Co NS) and methicillin-resistant coagulase-negative staphylococci (MRCN) , For anti-Co NS and anti-MRCN infection treatment provide a reference. Methods: From 2010 to 2015, 138 cases of pediatric patients admitted to our hospital with positive blood culture and in line with the diagnostic criteria of neonatal sepsis were selected. The pathogenic bacteria and drug susceptibility tests were retrospectively analyzed. Results: A total of 140 strains of pathogenic bacteria were detected in blood culture (136 strains were single strain and 2 were double strain). The highest detection rate of Co NS was 80.0% (112/140). There were 81 strains of MRCN and 1 strain of methicillin-resistant Staphylococcus aureus (MRSA) in 140 pathogens. The susceptibility tests of 81 strains of MRCN showed that the resistance rates to penicillin, ampicillin, amoxicillin / clavulanic acid, cefazolin, erythromycin, imipenem and clindamycin were 93.8% (76 / 81.5% (66/81), 75.3% (61/81), 72.8% (59/81), 64.2% (52/81) and 45.7% (37/81) No strains resistant to vancomycin and linezolid were found. Conclusion: The MRCN detection rate of neonatal sepsis in our hospital is high, and antibiotics should be used clinically to improve the clinical effect.