编码 P5 3蛋白的 P5 3基因是近年来发现的一种重要的抑癌基因 ,其突变和失活已被证实与许多肿瘤的发生、发展有关 ,已成为人们研究的热点 [1]。笔者对用甲醛固定、石蜡包埋的人鼻咽癌 (NPC)的组织切片应用免疫组化染色法检测 P5 3蛋白的表达 ,以了解其与 NPC的临床分期和生物行 P5 3 gene encoding P5 3 protein is an important tumor suppressor gene discovered in recent years. The mutation and inactivation of P5 3 gene have been proved to be associated with the occurrence and development of many tumors, and have become a hot research topic [1]. The author of formaldehyde fixed paraffin embedded human nasopharyngeal carcinoma (NPC) tissue sections using immunohistochemical staining P5 3 protein expression in order to understand its clinical stage and NPC of NPC