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一氧化氮(NO)是近年发现的一种由血管内皮分泌的能够调节血管内皮对乙酰胆碱的舒张反应的物质。它作用广泛,性质活跃。一氧化氮合酶(NOS)在中枢分布广泛,对于动物和人的学习、记忆、思维、情绪和应激反应均有密切的关系。NO不影响静息状态下内分泌细胞的功能,在应激时,NO对促肾上腺皮质激素释放因子(CRF)、促肾上腺皮质激素(ACTH)、加压素、肾上腺糖皮质激素的释放均有不同的影响。应激时,外周依赖NO氮能神经递质功能紊乱、器官组织局部的NO合成减少、免疫细胞功能下降也是心身疾病发生的原因之一。
Nitric oxide (NO) is a substance secreted by the vascular endothelium in recent years that regulates the relaxation of acetylcholine in the vascular endothelium. It is widely used and active in nature. Nitric oxide synthase (NOS) is widely distributed in the central nervous system, and is closely related to animal and human learning, memory, thinking, emotion and stress response. NO does not affect the function of endocrine cells under resting conditions. NO exerts different effects on the release of corticotropin releasing factor (CRF), adrenocorticotropic hormone (ACTH), vasopressin and glucocorticoid during stress Impact. Stress, peripheral NO-dependent neurotransmitter dysfunction, organ tissue synthesis of NO reduction in immune cell function is also one of the causes of psychosomatic disease.