论文部分内容阅读
目的 :研究某些感音神经性聋患者血清中是否存在抗内耳血管抗体。方法 :通过临床详细询问病史、纯音测听、声导抗测试及耳声发射筛查 ,选择耳蜗性聋患者 4 0 7例为研究对象 ,其中突发性耳聋 35例 ,Ménière′s病 4 1例 ,不明原因耳蜗性耳聋 331例。以豚鼠内耳石蜡切片作为抗原 ,用间接免疫荧光法检测患者血清中的抗内耳血管抗体。结果 :4 0 7例患者中有 6 9例血清中抗内耳血管抗体阳性 ,阳性率为 16 .95 %。其抗体类型有抗毛细血管内皮抗体 ,抗血管壁弹力纤维抗体 ,抗血管壁内膜和外膜抗体等。 6 9例患者中 ,单纯抗血管壁抗体阳性者 31例 ,占 4 4 .93% ,其余 38例患者还同时存在其它抗内耳抗体。在 6 9例患者中临床诊断突发聋者 12例 ,Ménière′s病者 13例 ,不明原因耳蜗性聋者 4 4例 ,占6 3.77%。 6 9例患者纯音测听结果显示低频听力下降者 4 2例 ,平坦型听力下降者 2 4例 ,高频听力下降者 3例。结论 :某些感音神经性聋患者血清中存在各种类型的抗内耳血管抗体。
Objective: To investigate the presence of anti-inner ear vascular antibodies in the serum of some sensorineural deaf patients. Methods: A total of 407 patients with cochlear deafness were enrolled in the study, including 35 patients with sudden deafness and Ménière’s disease 4 1, with clinical history, pure tone audiometry, acoustic impedance test and otoacoustic emission screening. Cases, 331 cases of unexplained cochlear deafness. The inner ear paraffin sections of guinea pigs were used as antigen, and anti-inner ear vascular antibodies in serum were detected by indirect immunofluorescence. Results: Among the 477 patients, 69 were positive for anti-inner ear antibody in serum, the positive rate was 16.95%. The antibody types are anti-capillary endothelium antibody, anti-vascular wall elastic fiber antibodies, anti-vascular wall and outer membrane antibodies. Of the 69 patients, 31 cases were positive for anti-vascular wall antibody, accounting for 44.43%. Other 38 cases also had other anti-inner ear antibodies. Of the 69 patients, 12 were diagnosed as sudden deafness, 13 as Ménière’s disease and 44 as unidentified cochlear deafness, accounting for 6 3.77%. The pure tone audiometry results of 69 patients showed 42 cases of low frequency hearing loss, 24 cases of flat type hearing loss and 3 cases of high frequency hearing loss. CONCLUSIONS: There are various types of anti-inner ear vascular antibodies in the serum of some sensorineural deaf patients.