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目的探讨小剂量利维爱在围绝经期综合征短期激素替代治疗中的应用。方法根据Kupperman评分,将72例重度绝经后围绝经期综合征妇女随机分为两组,予不同剂量(1.25 mg、2.5 mg)利维爱行激素替代治疗三周期。结果治疗后各项激素及生化指标与治疗前比较,雌二醇明显升高;促卵泡成熟激素、Kupperman评分及甘油三酯降低(P<0.05)。结论小剂量(1.25 mg)利维爱即能够调节重度围绝经期综合征妇女的体内激素水平,短期内改善围绝经期综合征症状。
Objective To investigate the application of low dose Levi in short-term hormone replacement therapy for perimenopausal syndrome. Methods According to the Kupperman score, 72 women with severe postmenopausal menopausal syndrome were randomly divided into two groups and treated with different doses (1.25 mg, 2.5 mg) of leviotherapy for three cycles. Results After treatment, the hormones and biochemical indexes were significantly higher in estradiol group than those before treatment. The follicle stimulating hormone, Kupperman score and triglyceride level were decreased (P <0.05). Conclusions Low-dose (1.25 mg) Levi Love regulates the hormone levels in women with severe perimenopausal symptoms and improves the symptoms of menopausal syndrome in the short term.