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对３０例中耳胆脂瘤肥大细胞进行组织化学与透射电镜观察，并与健康外耳道皮肤对照．结果发现中耳胆脂瘤肥大细胞明显多于正常对照组（Ｐ＜０．０１），主要分布范围包括上皮层、下皮下特别是近骨吸收面的肉芽组织内。电镜下大多数肥大细胞呈活化状态，与ＴＣ肥大细胞类似，呈无定型均质细颗粒状或毛玻璃样改变，肥大细胞贴壁的小静脉内见许多多形核白细胞溢出；活化肥大细胞主要呈“缓慢脱颗粒”状态；少数肥大细胞与成纤维细胞及浆细胞密切接触。讨论了肥大细胞在中耳胆脂瘤发病和发展中的可能作用。
Thirty patients with middle ear cholesteatoma were observed by histochemistry and transmission electron microscopy and compared with healthy external auditory canal skin. The results showed that the middle ear cholesteatoma mast cells were significantly more than the normal control group (P <0.01), the main distribution including the epithelium, subcutaneous, especially the proximal surface of the granulation tissue absorption. Under electron microscopy, most of the mast cells were activated. Similar to TC mast cells, they showed amorphous homogeneous fine granular or frosted glass-like changes. Many polymorphonuclear leukocytes were found in the small veins adherent to mast cells. The activated mast cells were mainly “Slow degranulation” state; a few mast cells and fibroblasts and plasma cells in close contact. The possible role of mast cells in the pathogenesis and progression of middle ear cholesteatoma is discussed.