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目的:探讨转化生长因子β1(TGFB1)基因T869C位点多态性与类风湿性关节炎(RA)易感性的关系。方法:检索PubMed、中国医学文献数据库,得到TGFB1基因T869C与RA易感性关系的病例-对照研究,并用Meta分析方法合并T869C与RA易感性关系的OR值。然后进行异质性分析、亚组分析和发表偏倚检验。结果:纳入符合标准的文献有7篇,共包括1 122例病例和1 132例对照,采用固定效应模型和随机效应模型发现,在任何模型下,T869C与RA的易感性无关。而种族分层分析发现,在亚洲人群中,T869C多态性位点在共显性模型和显性模型下能够增加罹患RA的危险性。结论:TGFB1基因T869C位点在亚洲人群中是RA的危险因素。
Objective: To investigate the relationship between T869C polymorphism of transforming growth factor β1 (TGFB1) gene and susceptibility to rheumatoid arthritis (RA). METHODS: A case-control study of the association between TGF-β1 gene T869C and susceptibility to RA was performed using PubMed and Chinese medical literature database. The OR of T869C susceptibility to RA was analyzed by Meta-analysis. Heterogeneity analysis, subgroup analysis, and publication bias tests were then performed. RESULTS: Seven articles were included in the criteria, including 1 122 cases and 1 132 controls. The fixed-effect model and the random-effect model were used to find that T869C was not associated with the susceptibility of RA in any of the models. Racial stratification analysis found that T869C polymorphism in Asian populations increased the risk of RA in both co-dominant and dominant models. Conclusion: The T869C site of TGFB1 gene is a risk factor for RA in Asian population.