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本研究制备了人白细胞介素2国家标准品并分析其特性,首先对人白细胞介素2活性测定进行了研究,保证了该方法的灵敏可靠,对标准品配方进行筛选,得到了最佳的配方.在完成标准品的制备后,国内外对效价进行了联合标定,确定了人白细胞介素2国家标准品的效价为400IC/支,经过2年6个月37℃等多种温度的保存,效价均未下降,经化学动力学实验表明,理论有效期在100年以上,说明我们研制的标准品稳定性达到了国际上人白细胞介素2标准品的水平.
In this study, human interleukin 2 national standard was prepared and its characteristics were analyzed. First, the determination of human interleukin 2 activity was carried out to ensure that the method was sensitive and reliable, and the standard formulation was screened to obtain the best Formula.After the preparation of the standard was completed, the titer was jointly calibrated at home and abroad, and the titer of the human interleukin 2 national standard was determined to be 400 IC / support. After 2 years and 6 months of 37 ° C and other temperatures The results showed that the validity of the theory was over 100 years, indicating that the stability of the standard we developed has reached the level of international human interleukin 2 standard.