蛋白激酶C(PKC)是一个由多基因编码的多功能同工酶家族 ,目前发现至少有 12种亚型。高血糖和游离脂肪酸可引起多种组织内二脂酰甘油 (DAG)水平升高 ,DAG可激活PKC。不同的PKC亚型可介导或抑制胰岛素的作用 ,促进葡萄糖代谢或引起胰岛素抵抗。研究表明 ,持续高血糖引起的DAG PKC系统激活与糖尿病多种血管并发症密切相关。选择性PKC β抑制剂LY3335 31在临床和动物实验中已取得满意疗效。 Protein kinase C (PKC), a multifunctional isoenzyme family encoded by multiple genes, is presently found in at least 12 subtypes. Hyperglycemia and free fatty acids cause elevated levels of diacetylglycerol (DAG) in various tissues, and DAG activates PKC. Different PKC subtypes can mediate or inhibit the effects of insulin, promote glucose metabolism or cause insulin resistance. Studies have shown that persistent hyperglycemia-induced DAG PKC system activation is closely related to various vascular complications of diabetes. The selective PKC β inhibitor LY3335 31 has achieved satisfactory results in clinical and animal experiments.