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目的 探讨鲨鱼软骨提取物 (SCE)灌胃对大鼠佐剂性关节炎 (AIA )的预防和治疗作用。方法 用 Freund完全佐剂注入实验大鼠右后足造成佐剂诱导性大鼠关节炎模型 ,观察鲨鱼软骨提取物对佐剂性关节炎的影响。结果 在致炎后 7d SCE灌胃 ,连续 7d,在 SCE剂量为 2 .5 ,10 .0 ,4 0 .0 mg/kg时 ,第 2 2天 AIA计分分别为 (6 .12± 0 .6 4 )、(5 .38± 0 .74 )、(4.5 0± 1.2 0 )分 ,体重分别为 (2 74± 15 )、(2 76± 16 )、(2 88± 9) g,与 AIA对照组 [计分为 (6 .38± 0 .74 )分 ,体重为 (2 6 3± 16 ) g]比较 ,差异均有显著性 (P<0 .0 5或 0 .0 1) ,提示 SCE可明显抑制 AIA症状。在致炎后 19d SCE灌胃 ,连续 7d,在剂量为2 .5 ,10 .0 ,4 0 .0 mg/kg时 ,第 38天其 AIA计分分别为 (6 .75± 0 .4 6 )、(5 .2 5± 0 .4 6 )、(4.88± 0 .35 )分 ,与 AIA对照组 [计分 (7.38± 0 .74 )分 ]比较 ,抑制率分别为 8.5 4 % ,2 8.86 % ,33.87% ,差异均有显著性(P<0 .0 5或 0 .0 1) ,明显抑制 AIA症状。结论 鲨鱼软骨提取物灌胃对大鼠佐剂性关节炎模型的继发性病变具有显著的预防和治疗作用。
Objective To investigate the preventive and therapeutic effects of intragastric administration of shark cartilage extract (SCE) on adjuvant arthritis (AIA) in rats. Methods Adjuvant-induced rat arthritis model was induced by injection of Freund complete adjuvant into the right hind paw of rats. The effect of shark cartilage extract on adjuvant arthritis was observed. Results The SCE was intragastrically administered 7 d after the inflammation, and continuously for 7 d. At the SCE doses of 2.5, 10, and 40 mg/kg, the AIA score on the 2nd day was (6 .12 ± 0). 6 4), (5.38±0.74), (4.5 0±1.2 0) points, weights (2 74 ± 15), (2 76 ± 16), (2 88 ± 9) g, and AIA There were significant differences (P<0.05 or 0.01) between the control group [score (6.38±0.74) points and body weight (2 6 3±16) g]. SCE can significantly inhibit AIA symptoms. The SCE was intragastrically administered for 19 days after the inflammation and continued for 7 days. At doses of 2.5, 10, and 40 mg/kg, the AIA scores on the 38th day were (6.75±0.44). ), (5.25 ± 0.46), (4.88 ± 0.35) points, compared with the AIA control group [score (7.38 ± 0.74) points], the inhibition rates were 8.54%, respectively. 2 8.86%, 33.87%, the difference was significant (P <0.05 or 0.01), significantly inhibited AIA symptoms. Conclusion The intragastric administration of shark cartilage extract has significant preventive and therapeutic effects on secondary lesions in rat adjuvant arthritis models.