Background:Spider nevi (SN) are quite common in children.SN are treated via different techniques,and complete removal often requires multiple treatments.However,few studies have evaluated the treatment of SN.The present study aimed to evaluate the therapeutic effect and safety of a 595-nm pulsed-dye laser (PDL) for treating facial SN in children.Methods:A total of 110 children aged 0.2 to 12 years with facial SN were treated with a 595-nm PDL in a single institution from January 2016 to February 2018.In accordance with the treatment method,the patients were retrospectively divided into the small-spot-combined-with-large-spot group (SL-group) and the large-spot group (L-group).Patients with poor therapeutic results were retreated every 6 weeks until the lesions disappeared.The minimum follow-up period was 1 year.The groups were compared using independent-samples t tests,Mann-Whitney U test,Chi-square test,and Fisher exact probability test.Results:The therapeutic efficacy was significantly higher in the SL-group than in the L-group,with clearance rates of 90.9％ and 53.0％ after the primary treatment,respectively (x =17.937,P ＜ 0.001).For skin lesions with a central spider body diameter ≥1 mm,the once-treatment cure rates were 100％ in the SL-group and 34.8％ in the L-group (x2 =20.780,P ＜ 0.001).For skin lesions with a central spider body diameter ＜1 mm,the once-treatment cure rates were 82.6％ in the SL-group and 62.8％ in the L-group (x2 =3.961,P =0.138).The rates of adverse reactions and recurrence did not differ between the two groups (P =0.141 and P =1.000,respectively).Conclusions:The 595-nm PDL might be a safe and effective treatment option for facial SN in children.The small-spot-combined-with-large-spot method is especially suitable for SN with a central spider body diameter ≥1 mm.