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最早报告恶性疟原虫对抗疟药产生抗性的,是1910年Nocht等报告在巴西发现对奎宁(quinine)产生抗药性。以后又发现对乙胺嘧啶(Pyrimethamine)产生抗药性。60年代初期,在哥伦比亚、南美洲、泰国和东南亚地区又分别报道发现恶性疟原虫对氯喹(Chloroquine)产生了抗药性。其后,抗氯喹虫株出现的范围不断地扩大,同时,产生抗药性的药物也不断增多。我国自70年代以来,已先后证实粤、桂、滇、黔、闽、苏,皖、豫等八省(区)均有恶性疟原虫抗氯喹株存在,其中尤以海南岛和云南南部地区最为严重。海南岛近年还出现了恶性疟原虫对喹哌(Piperaqui
The earliest reported resistance of Plasmodium falciparum to anti-malarial drugs was reported in 1910 by Nocht et al. In Brazil for its resistance to quinine. Later it was found to be resistant to pyrimethamine. In the early 1960s, Plasmodium falciparum was also reported to be resistant to chloroquine in Colombia, South America, Thailand and Southeast Asia respectively. Since then, the scope of the emergence of chloroquine resistant strains has continued to expand, at the same time, drug-resistant drugs have also been increasing. Since the 1970s, China has confirmed the presence of chloroquine-resistant strains of Plasmodium falciparum in eight provinces (autonomous regions) of Guangdong, Guangxi, Yunnan, Guizhou, Fujian, Jiangsu, Anhui and Henan provinces, especially in Hainan Island and southern Yunnan serious. Hainan Island in recent years also appeared in Plasmodium falciparum (Piperaqui