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Fas(Apo- 1/ CD95)是一 4 5k Da 型膜蛋白 ,Fas-配基 (Fas L)是一 37～ 4 0 k Da 型膜蛋白 ,均属于肿瘤坏死因子受体及其配基族。Fas被某些抗 - Fas抗体或Fas L激活则可引起敏感细胞的凋亡性细胞死亡。Fas-Fas L之间的相互作用可介导 T细胞毒性、调节免疫反应、组织发生和内环
Fas (Apo-1 / CD95) is a 45 kDa membrane protein and Fas-Ligand is a 37-40 kDa membrane protein belonging to the tumor necrosis factor receptor and its ligand family. Activation of Fas by certain anti-Fas antibodies or Fas L can cause apoptotic cell death in sensitive cells. The interaction between Fas-Fas L mediates T-cell cytotoxicity, modulates immune responses, tissue development, and inner loop