经口给各种抗原可产生稳定的体液和细胞介导的抗原特异性免疫耐受性。然而经口给抗原也能引起胃肠道内IgA的产生,并引起血清抗体应答。控制经口给抗原后所发生的各种抗体产生和调节的自稳机制内在复杂性导致了这些矛盾现象。目前有关免疫系统对天然食物抗原如何应答了解甚少。本文用纯系大鼠研究发育早期阶段经食物接触卵白蛋白对以后相应特异性抗体应答的影响。发育中的免疫系统通过在宫内和/或产后一定时间内及给哺乳鼠饲含卵白蛋白食物接触卵白蛋白。子代断奶饲常规食物,以后经胃肠外和/或经口用卵白蛋白攻击,检测抗体应答性质。作者用健康无病原菌的PVG系雌雄大鼠,喂 Oral administration of various antigens produces stable humoral and cell-mediated antigen-specific immune tolerance. However, oral administration of antigens can also cause the production of IgA in the gastrointestinal tract and cause a serum antibody response. The inherent complexity of the self-stabilizing mechanism that controls the production and regulation of various antibodies that occur after oral administration to antigens leads to these paradoxical phenomena. Little is known about how the immune system responds to natural food antigens. In this paper, pure rats were used to study the effect of food-contact ovalbumin on the corresponding specific antibody response in the early stages of development. The developing immune system contacts ovalbumin by administering ovalbumin-containing food intrauterine and / or within a certain period of time after delivery and to nursing rats. Progeny were weaned for conventional foods and then challenged with antibody against parenteral and / or oral ovalbumin challenge. The author uses healthy pathogen free PVG male and female rats, fed