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目的观察硝酸甘油、低分子肝素对慢性肺心病患者心功能的影响。方法对收治的42例慢性肺心病病人随机分为两组,对照组20例,采用低流量吸氧,控制感染、解痉平喘、强心利尿,纠正水电解质平衡紊乱等内科常规综合治疗。治疗组22例在上述常规治疗的基础上加用硝酸甘油10～25mg于5%葡萄糖中静滴,每日1次,同时予以腹壁皮下注射低分子肝素4000U,每天2次,7天为一个疗程。结果治疗后,两组病人临床心功能均有改善,治疗组左室射血分数提高明显好于对照组,且差异有显著性。结论硝酸甘油、低分子肝素联合治疗能够改善慢性肺心病患者的心功能,值得推广应用。
Objective To observe the effects of nitroglycerin and low molecular weight heparin on cardiac function in patients with chronic cor pulmonale. Methods Forty-two patients with chronic pulmonary heart disease admitted to our hospital were randomly divided into two groups. The control group consisted of 20 cases. The patients were treated with low-flow oxygen inhalation, infection control, antispasmodic and antiasthmatic effects, cardiac diuretic, and water and electrolyte balance disorders. 22 cases of treatment group on the basis of the above conventional treatment plus nitroglycerin 10 ~ 25mg intravenous infusion of 5% glucose once daily, while subcutaneous low molecular weight heparin 4000U, 2 times a day, 7 days for a course of treatment . Results After treatment, the clinical cardiac function was improved in both groups. The left ventricular ejection fraction in the treatment group was significantly higher than that in the control group, and the difference was significant. Conclusions Nitroglycerin and low molecular weight heparin can improve cardiac function in patients with chronic cor pulmonale, which is worth popularizing and applying.