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目的 探讨庚型肝炎病毒 (HGV)感染在慢性肝炎中的临床意义。方法 以逆转录巢式聚合酶链反应检测慢性肝炎患者血清HGVRNA。结果 HGVRNA阳性率在慢性乙、丙型肝炎分别为 6 .8% (4 5 9)和 2 0 .0 % (18 90 )。比较HGVRNA阳性和阴性 2组慢性肝炎患者血清ALT、AST及BIL水平及临床分型均无明显差异 (P >0 .0 5 )。结论 重叠HGV感染对慢性乙、丙型肝炎的病情无明显影响 ,提示HGV对慢性肝炎的致病性可能较弱
Objective To investigate the clinical significance of hepatitis G virus (HGV) infection in chronic hepatitis. Methods Reverse transcriptase nested polymerase chain reaction was used to detect serum HGVRNA in patients with chronic hepatitis. Results The positive rate of HGVRNA was 6.8% (459) and 20.0% (18 90) in chronic hepatitis B and C respectively. There was no significant difference in serum ALT, AST and BIL levels and clinical classification between HGV RNA positive and negative group 2 chronic hepatitis patients (P> 0.05). Conclusions The overlap HGV infection has no obvious effect on chronic hepatitis B and C, suggesting that the pathogenicity of HGV to chronic hepatitis may be weak