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作者曾报道,用过氧化物酶标记的抗体染色技术,通过光学和电子显微镜检查,证实实验性感染人甲型肝炎病毒(HAV)的狨猴肝组织分布有病毒抗原(HAAg);在感染HAV的黑猩猩的肝细胞中也见类似现象;在肝细胞和枯否氏细胞的胞浆内空泡中存在有病毒样颗粒(24～27nm)。但检测人肝中HAAg未见成功。本文报道用相同技术,发现在一名甲型肝炎急性期患者的肝活检组织中存在有HAAg。该患者女性,23岁,发病9天入院,发热38.2℃,有黄疸,肝大,触痛,脾和淋巴结不肿大。SGOT 3540,SGPT 5076,总胆红素与直接胆红素6.3/3.2mg,硷性磷
The authors have reported that by peroxidase-labeled antibody staining techniques, optical and electron microscopic examination confirmed the presence of viral antigens (HAAg) in the liver of experimental monkeys infected with Hepatitis A virus (HAV) Of chimpanzee liver cells also see a similar phenomenon; in hepatocytes and Kupffer cells within the cytoplasmic vacuoles of virus-like particles (24 ~ 27nm). However, the detection of HAAg in human liver has not been successful. This article reports the same technique and found that HAAg is present in a liver biopsy in an acute hepatitis A patient. The female patient, 23 years old, admitted to hospital for 9 days with fever of 38.2 ℃, had jaundice, hepatomegaly, tenderness, and no enlargement of spleen and lymph nodes. SGOT 3540, SGPT 5076, total bilirubin and direct bilirubin 6.3 / 3.2 mg, alkaline phosphorus