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目的:综合评价一氧化氮合酶3(nitric oxide synthase 3,NOS3)基因多态性(894G>T)与前列腺癌易感性的关系。方法:利用计算机检索Cochrane Library、PubMed、EMBase、中国知网、万方和维普等数据库,按照文献纳入标准和排除标准选择研究文献,评价文献质量,并提取资料。采用STATA 12.0软件进行Meta分析,计算NOS 3 894G>T与前列腺癌易感性关系的合并比值比(odds ratio,OR),并进行亚组分析、敏感性分析和发表偏倚检验。结果:终纳入5项病例-对照研究,共包括3 078例患者和3 677例正常对照。Meta分析结果显示,NOS 3 894G>T基因多态性与前列腺癌易感性之间无显著相关性[TT vs GG,OR=0.95,95%可信区间(coni dence interval,CI):0.80~1.14;TT vs GT,OR=0.88,95%CI:0.73~1.05;TT+GT vs GG,OR=1.07,95%CI:0.97~1.18;TT vs GG+GT,OR=0.92,95%CI:0.77~1.09]。种族亚组分析中,在欧洲人群中发现两者也无显著相关性[TT vs GG,OR=0.87,95%CI:0.73~1.04;TT vs GT,OR=0.85,95%CI:0.71~1.02;TT+GT vs GG,OR=1.00,95%CI:0.90~1.11;TT vs GG+GT,OR=0.86,95%CI:0.72~1.02]。结论:NOS 3 894G>T基因多态性与前列腺癌易感性之间不存在关联性,在欧洲人群中亦无关联性。
Objective: To evaluate the relationship between the polymorphism of nitric oxide synthase 3 (894G> T) and the susceptibility to prostate cancer. Methods: The databases of Cochrane Library, PubMed, EMBase, CNKI, Wanfang and Vipu were searched by computer. The research documents were selected according to the inclusion criteria and exclusion criteria, the quality of the literature was evaluated, and the data were extracted. Meta-analysis was performed using STATA 12.0 software to calculate the odds ratio (OR) for the relationship between NOS 3 894G> T and susceptibility to prostate cancer. Subgroup analyzes, sensitivity analyzes, and publication bias tests were also performed. Results: Five case-control studies were included, including 3 078 patients and 3 677 normal controls. Meta-analysis showed no significant association between NOS 3 894G> T polymorphism and susceptibility to prostate cancer [TT vs GG, OR = 0.95, 95% confidence interval (CI): 0.80 to 1.14 ; TT vs. GT, OR = 0.88, 95% CI: 0.73 to 1.05; TT + GT versus GG OR = 1.07, 95% CI: 0.97 to 1.18; TT vs. GG + GT, OR = 0.92, 95% CI: 0.77 ~ 1.09]. In the ethnic subgroup analysis, there was also no significant correlation between the two in the European population [TT vs GG, OR = 0.87, 95% CI: 0.73 to 1.04; TT vs GT, OR = 0.85, 95% CI: 0.71 to 1.02 ; TT + GT vs GG, OR = 1.00, 95% CI: 0.90-1.11; TT vs. GG + GT, OR = 0.86, 95% CI: 0.72-1.02]. CONCLUSION: There is no association between NOS 3 894G> T polymorphism and susceptibility to prostate cancer, nor is there association among European populations.