为探讨ＰＣＮＡ 在喉鳞癌中的表达及与临床间的关系，对３７ 例喉原发性鳞癌、癌旁１０ｃｍ 组织及２０ 例声带息肉组织进行了检测，采用免疫组化ＬＳＡＢ 法。结果：喉癌组与癌旁组阳性表达率差异非常显著（ Ｐ ＜ ００１） ，与声带息肉组之间阳性表达率差异显著（ Ｐ ＜ ００５） 。ＰＣＮＡ 组织分化低者表达高，高低分化表达率相比较差异显著（ Ｐ ＜ ００５） 。在有颈淋巴结转移者中ＰＣＮＡ 的表达明显高于未转移者（ Ｐ＜ ００５） 。笔者认为，ＰＣＮＡ 在喉癌细胞的生长调控中起着重要作用，对判断预后及颈部转移可能起着指导意义 To investigate the expression of PCNA in laryngeal squamous cell carcinoma and its relationship with clinic, 37 cases of primary laryngeal squamous cell carcinoma, 10cm paraneoplastic adjacent tissues and 20 cases of vocal cord polyps were examined by immunohistochemical LSAB method. Results: There was a significant difference in the positive expression rate between laryngeal carcinoma and paracancer (P <001). The positive expression rate was significantly different from that in vocal cord polyps (P <005). The expression of PCNA in the low differentiation group was higher than that in the low differentiation group (P <005). The expression of PCNA in patients with cervical lymph node metastasis was significantly higher than those without metastasis (P <005). The author believes that PCNA plays an important role in the regulation of the growth of laryngeal carcinoma cells and may be instructive in judging prognosis and neck metastasis