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1992年11月至1993年4月对确诊新生儿缺氧缺血性脑病(HIE)的45例患儿,系统地观察了入院日及5～7天后的血、尿电解质,渗透压及抗利尿激素(ADH)改变,其中10例符合抗利尿激素异常分泌综合征(SIADH)。结合临床讨论了 SIADH 的发病、诊断及治疗。提出不宜给予高渗钠(3%氯化钠)治疗,可限水,应用利尿及脱水剂或补充2%～2.5%碳酸氢钠。临床应警惕 HIE 并发 SIADH,防止低血钠、低渗透压血症引起脑细胞水肿加重,防止原发病加重及恶化,并给予相应治疗,以提高HIE 治愈率。
From November 1992 to April 1993, 45 children with confirmed neonatal hypoxic-ischemic encephalopathy (HIE) were systematically observed for blood, urine electrolytes, osmotic pressure and antidiuresis on admission day and 5-7 days Hormone (ADH) changes, including 10 cases of antidiuretic hormone secretion syndrome (SIADH). Combined with the clinical discussion of the incidence of SIADH, diagnosis and treatment. Proposed should not be given hypertonic sodium (3% sodium chloride) treatment, may limit water, the application of diuretic and dehydrating agent or added 2% to 2.5% sodium bicarbonate. Clinical should be alert to HIE complicated with SIADH, to prevent hyponatremia, hypo osmoticmia caused by increased brain cell edema, to prevent the aggravation and deterioration of the original disease, and give the appropriate treatment to improve the cure rate of HIE.