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我院自1985年1月至1992年12月对38例经组织学或细胞学证实的中晚期非小细胞肺癌,采用化放综合治疗,其中鳞癌22例,腺癌14例,大细胞癌2例,临床分期Ⅱ期6例,Ⅲ_a12例,Ⅲ_b15例,Ⅳ期5例,结果完全缓解率为21.1％(8/38),部分缓解率为36.8％(14/38),总有效率为57.8％(22/38)。1、2、3年生存率分别为63.6％、31.6％和15.8％,中位生存期为14.5月。化疗毒性反应主要为恶心呕吐和骨髓抑制,放疗毒性反应为肺纤维化和放射性肺炎。作者认为先用化疗可能为微小转移灶做早期治疗,后加用放疗能使肺部肿瘤进一步缩小,延长病人的生存期,值得进一步扩大研究。
In our hospital from January 1985 to December 1992, 38 cases of advanced or advanced non-small cell lung cancer confirmed by histology or cytology were treated with comprehensive chemotherapy, including 22 cases of squamous cell carcinoma, 14 cases of adenocarcinoma, and large cell carcinoma. In 2 patients, clinical stage II was 6 cases, III_a12 cases, III_b15 cases, and IV stage 5 cases. The complete remission rate was 21.1% (8/38), and the partial remission rate was 36.8% (14/38). The total effective rate was 57.8% (22/38). The 1-, 2-, and 3-year survival rates were 63.6%, 31.6%, and 15.8%, respectively, and the median survival time was 14.5 months. The toxicities of chemotherapy were mainly nausea, vomiting and myelosuppression. The toxicities of radiotherapy were pulmonary fibrosis and radiation pneumonitis. The authors believe that chemotherapy may be used for the early treatment of micrometastases. The addition of radiotherapy can further shrink the tumor in the lung and prolong the patient’s survival. It is worth further research.