A number of imPOrtant methodological developments in high resolutiOn NMR spec-troscopy have led to significant increases in the size limitations that previously imPeded solu-tion structural studies of rnacrOmolecules. SPeCifically, isotope labeing and TRO A number of imPOrtant methodological developments in high resolutiOn NMR spec-troscopy have led to significant increases in the size limitations that previously imPeded solu-tion structural studies of rnacrOmolecules. SPeCifically, isotope labeing and TRO