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目的研究阿托伐他汀对急性脑梗死患者血清 C 反应蛋白(CRP)的影响,并分析其临床意义。方法对2003年4月至2005年8月东风汽车公司茅箭医院内科收治的62例经 CT 或 MRI 确诊的急性脑梗死患者,随机分为两组,两组均给予常规治疗,治疗组在此基础上予阿托伐他汀20 mg,每晚1次口服,分别在确诊24 h 内和治疗2周时使用免疫比浊法测定两组患者 CRP 水平。结果治疗组治疗2周后血清 CRP 明显降低,与对照组比差异有统计学意义。结论阿托伐他汀可以显著降低急性脑梗死患者血清 CRP 水平,对脑梗死病情变化及预后具有一定意义。
Objective To study the effect of atorvastatin on serum C-reactive protein (CRP) in patients with acute cerebral infarction and to analyze its clinical significance. Methods Sixty-two patients with acute cerebral infarction diagnosed by CT or MRI from April 2003 to August 2005 in Dongjiang Motor Company Maojian Hospital were randomly divided into two groups, the two groups were given conventional treatment, the treatment group in this On the basis of atorvastatin 20 mg orally once per night, respectively, within 24 hours of diagnosis and 2 weeks of treatment using immunoturbidimetry CRP levels of two groups of patients. Results After treatment for 2 weeks in treatment group, serum CRP was significantly lower than that in control group, and the difference was statistically significant. Conclusions Atorvastatin can significantly reduce the level of serum CRP in patients with acute cerebral infarction, which has certain significance for the changes and prognosis of cerebral infarction.