论文部分内容阅读
N~6-(2-羟乙基)腺苷(简称HEA)是虫草菌丝体中得到的第一个生物来源的钙离子拮抗剂,具有抑制癌细胞生长、降低炎症反应、保护肾脏、镇静、镇痛和抗惊厥等多种功效,已经成为一个研究热点。本文对HEA的菌株来源、生理功能、生物合成、提取纯化、化学合成的研究现状等方面进行了总结,对有关专利进行了评价和分析,提出从种质资源入手拓宽HEA来源,优化HEA的提取纯化方法,并深入探究其生物合成途径,为HEA的深入研究和开发应用提供指导。
N ~ 6- (2-hydroxyethyl) adenosine (abbreviated as HEA) is the first biological source of calcium antagonist obtained from mycelia of Cordyceps sinensis, and has the effects of inhibiting the growth of cancer cells, reducing the inflammatory reaction, protecting the kidneys and sedation , Analgesic and anticonvulsant and other effects, has become a research hotspot. In this paper, the origin, physiological functions, biosynthesis, extraction and purification of HEA and the current research status of chemical synthesis were summarized. The patents were evaluated and analyzed, and the sources of HEA were broadened from germplasm resources to optimize the extraction of HEA Purification methods, and in-depth exploration of its biosynthetic pathway for the further study of HEA and provide guidance for the development and application.