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目的:探讨高原地区脑梗死(CI)急性期使用不同剂量阿司匹林(ASP)对患者高敏C反应蛋白(hs-CRP)、D-二聚体的影响。方法:将90例来自高原地区的CI患者随机分为ASP 50mg组(A组)、100mg组(B组)、300mg组(C组),检测3组治疗前后血清hs-CRP、D-二聚体及NINHSS评分变化,并与正常对照组(D组)比较。结果:治疗前A、B、C组hs-CRP、D-二聚体明显高于对照组(P<0.001),治疗2周后,hs-CRP降低幅度C组>B组>A组(P<0.05或0.01),D-二聚体降低幅度C组>B组>A组(P<0.05或0.01),显效率C组>B组>A组(P<0.05或0.01)。结论:脑梗死急性期hs-CRP、D-二聚体明显升高,发病2周内给予大剂量阿司匹林可以使D-二聚体及hs-CRP下降更明显,疗效优于小剂量组。
Objective: To investigate the effect of different doses of aspirin (ASP) on high-sensitivity C-reactive protein (hs-CRP) and D-dimer in patients with acute cerebral infarction (CI) in high altitude area. Methods: Ninety patients with CI from the plateau were randomly divided into ASP 50mg group (A group), 100mg group (B group) and 300mg group (C group). Serum hs-CRP and D-dimer Body and NINHSS score changes, and compared with the normal control group (D group). Results: The hs-CRP and D-dimer in groups A, B and C before treatment were significantly higher than those in control group (P <0.001). After 2 weeks of treatment, the reduction of hs-CRP in group C> <0.05 or 0.01). The decrease of D-dimer in C group> B group> A group (P <0.05 or 0.01), C group> B group> A group (P <0.05 or 0.01). CONCLUSIONS: The hs-CRP and D-dimer in acute stage of cerebral infarction are obviously increased. High-dose aspirin within 2 weeks can make the decrease of D-dimer and hs-CRP more obvious, and the effect is better than the low dose group.